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Glyceryl Trinitrate - page 6
Keywords: GTN, Glyceryl trinitrate, Nutrition and Energy
By Einstein10 on 30/12/2009
Level: Foundation Degree
Page Number: 6 of 6 pages: 1 2 3 4 5 6arrythmias and fatal cardiac arrest. The risk of ventricular arrythmias increased with liver disease, overdose and concomitant administration of other drugs. The peak plasma concentration of terfenadine after concomitant use of ketoconazole or grapefruit juice was shown to be as high as 50 ng/ml.
14. Explain why terfenadine clearance is reduced in patients with liver disease or after overdose (6 marks).
15. What is the significance of the interaction, described above, between terfenadine and ketoconazole or grapefruit juice (8 marks) ?
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