Cash4Coursework has been rebranded ‘FreeCoursework.info’ - Visit us to download coursework for free and to earn money from your old coursework!
View this page at Freecoursework.info
Glyceryl Trinitrate - page 2
Keywords: GTN, Glyceryl trinitrate, Nutrition and Energy
By Einstein10 on 30/12/2009
Level: Foundation Degree
Page Number: 2 of 6 pages: 1 2 3 4 5 6at least some of the hepatic metabolism described earlier resulting in an increased number of metabolites. These routes of administration give almost immediate relief to the patient because of their quick and efficient mechanism of action. For example, a sublingual spray of 0.15-0.6 mg of GTN is absorbed through the sublingual and lingual mucosa of the tongue giving an onset affect in between 1-3 min, a peak affect between 4-5 min and can last for up to 30 minutes as shown in table 1. The fastest known method for this type of administration is inhalation of amyl trinitrate with an immediate affect in 15-30 seconds but lasts for only 1 minute. If the patient was admitted in hospital at the time of the attack they could be given an I.V drip which also has immediate affect. The advantage of having so many different formulations of GTN is that if a patient is unable to take a sublingual tablet, they can be given a lingual spray which has the same immediate affect and lasting duration. The opposite can be said for a lingual spray.
Alternatively, Transdermal patches and buccal tablets can be used to permit slow release of GTN to prolong its duration of action. This method is adopted for patients who have a frequent history or a very high risk of acquiring ischemic heart disease and acute angina. For example, a 1-13 mg buccal tablet in an inert matrix can be held between the upper lip and gum which can give a slow release of GTN over a period of 4-8 hours. This is a better way of controlling the symptoms of patients with these conditions as it prevents angina attacks and an infarction, greatly reducing the chances of if happening.
Comparison between Transdermal patch and Sublingual tablet
Formulation
Sublingual Tablet Transdermal Patch
Normal dosage 0.15-0.6 mg 5,10,15 mg
Onset of Effect 1-3 Min 40-60 Min
Peak Affect 4-8 Min 60-180 Min
Lasting Duration 30-60 Min 8-24 Hours
Comparison between Onset and Duration of Action of Sublingual tablet and Transdermal patch
The onset of the sublingual tablet is very quick because the tongue is a much vascularised organ and therefore has a very rich blood supply. So when tablet is placed under the tongue is dissolves almost immediately and absorbs through the sublingual and lingual mucosa of the tongue and because of the high vasculature of the tongue it enters the systemic circulation rapidly. Secondly, this type of administration avoids at least some of the steps
Last 5 comments…
There have been no comments posted for this article, but you need to register if you want to be the first!