Cash4Coursework has been rebranded ‘FreeCoursework.info’ - Visit us to download coursework for free and to earn money from your old coursework!
View this page at Freecoursework.info
Drug Monograph on Rifampicin - page 2
Keywords: rifampicin, drug monograph, pharmacology, efficay, therapeutic uses, pharmacodynamics, Prophylaxis of meningococcal meningitis rifampin rifadin SA infections tuberculosis essay on rifampicin pharmacokinetics absorption distribution matabolism excretion bmj referecing
By Einstein10 on 30/12/2009
Level: Foundation Degree
Page Number: 2 of 11 pages: 1 2 3 4 5 6 7 8 9 10 11of a few bases, conformational changes occur that allow the protein to enter the elongation phase during which a processive motion of RNAP allows synthesis of RNA from the DNA template. 4
The binding of Rifampicin to RNAP occurs deep in a pocket of RNAP beta subunit deep within the DNA/RNA channel but the closest that Rifampicin can get is 12 amino acid residues away from the active site, Mg2+. 4 When the RNA transcript becomes 2 or 3 nucleotides long the 5th phosphate of the 5th nucleotide at -2 shown above as well as -3 to -5 clash strongly with the Rifampicin molecule. By doing there is a total blockage of transcripts initiated with nucleoside triphosphates are blocked after the first phosphodiester bond and transcripts started by the nucleoside diphosphates or monophosphates are blocked after the second phosphodiester bond. This causes a block in the path of the elongating RNA transcript at the 5’ end. 5 However, if RNAP is successful in synthesizing a long transcript and enters the elongation phase, it becomes resistant to Rifampicin. 5
Therapeutic Uses of Rifampicin
Disease/Overview of Disease Adult Dose Child Dose
Leprosy- A disease caused by Mycobacterium leprae which attacks the nervous system, especially the feet, hands and face. Leprosy sufferers commonly don’t feel any pain in these areas and consequently hurt themselves without releasing.
600 mg/month
450mg/month
Brucellosis- Brucelloris is caused by the bacterium brucella abortus and is intracellular bacteria that penetrate spread within the phagosomes of alveolar macrophages and blood monocytes.People that have ingested unpasteurized milk or meat from infected animals, or get in contact with these animals can usually get infected.
600-900 mg Orally once daily 10-15mg/kg/daily in one or two doses
Legionellosis- Legionellosis is a bacterial infection caused by Legionella pnuemophila. Sufferers get fever, chills, cough and a dry sputum 15 mg/kg per day maximum, 600 mg 15 mg/kg per day maximum, 450 mg
Serious staphylococcal infections-
Staphylococcus aureus is a spherical bacterium usually found on the nose and skin of normal people. It can cause skin infections, boils, and cellulitis. Folliculitis and many more conditions. 15 to 20 mg/kg/day 15 to 20 mg/kg/day
Prophylaxis of meningococcal meningitis- Meningitis is caused by bacteria called Meningococcal septicaemia and can cause inflammation of the membranes that cover the spinal cord and the brain. Present with a rash that can spread in the whole body 600 mg twice daily for 2 days 1 to 12 years 10 mg/kg bodyweight
3 to 12 months 5 mg/kg bodyweight
Prophylaxis of Haemophilus
Last 5 comments…
There have been no comments posted for this article, but you need to register if you want to be the first!